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Scientists Create Woolly Mice

Scientists have created woolly mice in a lab as part of a project that aims to recreate an extinct animal called the woolly mammoth.

Two mice with long golden fur sit with a white background.

Courtesy of Colossal Biosciences

Genetics company Colossal Biosciences created “woolly mice.”

Hundreds of thousands of years ago, a giant hairy animal roamed the Earth—the woolly mammoth. Though mammoths are now extinct, a genetics company says it is one step closer to bringing them back with the creation of a much smaller animal—the woolly mouse.

Scientists at Colossal Biosciences in the United States have created “woolly mice” with the shaggy, golden-brown hair of mammoths. The scientists altered the genetics of the mice to give them the same woolly trait that mammoths had.

“We ended up with some absolutely adorable mice that have longer, woolly, golden-colored coats,” Beth Shapiro, chief science officer at Colossal, told NPR.

Colossal is a company that hopes to use genetic modification to bring back extinct species like the mammoth. The woolly mice are the first step in this process.

Changing Mouse Genes

Genes dictate all of an organism’s physical and biological traits, like body size and eye color. Altering an organism’s genes can lead to changes in these biological traits, but it is a complicated and difficult process. 

Scientists can alter genes through adding, modifying, or replacing the DNA of an organism. Genetic information collected from mammoths found frozen in ice and permafrost has allowed researchers at laboratories like Colossal to identify which genes cause mammoth traits like shaggy hair. They can then make changes in other organisms, like the mice, to give them mammoth-like traits.

“This is the way that we’re going to create mammoths for the future,” Shapiro told NPR.

Is It a Mammoth?

Colossal aims to eventually alter the genes of Asian elephants, which are the mammoth’s closest living relatives. By starting with lab mice, scientists could first try genetic modification on a much smaller scale.

“The Colossal Woolly Mouse marks a watershed moment in our de-extinction mission. This success brings us a step closer to our goal of bringing back the woolly mammoth,” said Ben Lamm, the cofounder of Colossal.

However, other scientists are skeptical that genetic modification can be used to return the mammoth from extinction. Tori Herridge, a scientist from the University of Sheffield in the United Kingdom, told CNN that it will be much more challenging to make genetic changes in elephants than in mice. Changing these traits to an elephant’s DNA will create something that resembles a mammoth but will not be the real thing, she said.

“You are never going to ‘bring back’ a mammoth,” said Herridge.

The scientists at Colossal are focusing on bringing back not just the mammoth, but other extinct species as well. One of these species is the Australian thylacine—also called the Tasmanian tiger—which humans hunted into extinction in the early 1900s.

Did You Know?

Flutes made from mammoth ivory, or tusks, are some of the oldest musical instruments archaeologists have found. Some mammoth ivory flutes, found in a cave in southern Germany, are nearly 43,000 years old!

An ivory flute in two pieces is against a black background.

Courtesy of University of Tubingen

This flute, which is tens of thousands of years old, is made of mammoth ivory.

The Mammoths of Wrangel Island

Illustration of a woolly mammoth on a snowy landscape with mountains and trees in the background.

© Orla—iStock/Getty Images

Woolly mammoths went extinct about 10,000 years ago. Or did they?

The discovery of an isolated population of woolly mammoths that existed for another 6,000 years has changed what we know about mammoth extinction. On an island off the coast of Siberia, a region in modern-day Russia, mammoths continued to thrive long after the rest of their kind died off on the continents.

Scientists believe that sea ice connected Wrangel Island to the continental mainland and that mammoths migrated between the island and mainland for some time. When the sea ice melted, a small group of mammoths were stuck on the island. The size of the island is about 2,900 square miles (7,600 square kilometers), which is just a little smaller than Yellowstone National Park in the United States.

The Wrangel Island mammoths survived the rapid climate change that caused their mainland relatives to lose their habitat. The island mammoths maintained a relatively healthy breeding population for another 200 generations. This means that mammoths still existed while humans were building the pyramids in Egypt!

Sadly, extinction eventually came for Wrangel Island mammoths too. Researchers estimate that this population met its demise about 4,000 years ago.

“What happened at the end is a bit of a mystery still—we don’t know why they went extinct after having been more or less fine for 6,000 years, but we think it was something sudden,” said Love Dalén to BBC. Dalén is one of the researchers studying the Wrangel Island mammoth genes.

While researchers like Dalén work to solve this extinction mystery, Wrangel Island’s story is far from over. Today the island has the highest density of polar bear dens, approximately 400 every year. Mother bears give birth and raise cubs there during the summer while they wait for the Arctic Sea ice to freeze.

Wrangel Island, the last refuge for the mammoth, may be helping yet another vulnerable species keep extinction at bay.

Mammoth and Mastodon

One man stands on a ladder working on a reconstructed mammoth skeleton while two other men stand on the floor holding the mammoth’s tusks.

© Thomas Lohnes/Getty Images

How are today’s elephants related to the extinct woolly mammoth? Learn about this—and another extinct relative, the mastodon—at Britannica!

WORD OF THE DAY

extinct

PART OF SPEECH:

adjective

Definition:

no longer existing

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